2006


Rapid Non-Invasive Assessment of Compound-induced Effects
on Growth of Unlabelled Primary Human Cell Cultures

Bieke Govaerts, Marc Moeremans, Kris Ver Donck, Luc Bols and Johan Geysen

Oral presentation  at: ‘Knowledge for Growth’ Conference, Flanders Expo, Gent, Belgium, 16 June 2006.

Abstract 

 

Use of a New Self-learning Bio-imaging Software to Study Small Molecule
Induced Lipid Accumulation In Primary Cultures of Human Epidermal Keratinocytes

Marc Moeremans, Bieke Govaerts, Luc Bols, Kris Ver Donck, Yves Willems and Johan Geysen

Poster presented at: ‘Knowledge for Growth’ Conference, Flanders Expo, Gent, Belgium, 16 June 2006.

Abstract  |  Poster

 

Rapid Non-invasive Assays for Cell Growth and Inhibitory Effects of Compounds
on Primary Cultures of Human unlabeled Cells

Marc Moeremans, Kris Ver Donck, Bieke Govaerts, Luc Bols, Leen Geuens, Johan Geysen

Poster presented at: ISAC, XXIII International Congress, Québec City Convention Centre, May 20-24, 2006.

Abstract  |  Poster

 

The Potential and Promise of Label-free Technologies
for More Accurate Readings in Any Biologically Based Screen

Johan Geysen

Orally presented at the conference: “Compatible & Integrated Systems for Improved Biological Screening:  
Optimizing cell-based assays through compatible platforms, data management and assay integration” 
May 16-17, London, UK.

Abstract  |  Slides

 

From “High Content Screening” to “Robust Machine Vision Solutions”
for Genomics, Translational Science, Cloning, Bio-production, & (Stem-) Cell Therapy

Johan Geysen

Presented at: ‘6th Annual Discovery Summit  April 10-12, 2006, Monaco

Abstract  |  Slides

 


2005


Non-Invasive Assessment of Cell Growth, Confluence and

Compound-induced Inhibition on Unlabelled Primary Human Cell Cultures

Kris Ver Donck, Peter Van Osta, Luc Bols, Marc Moeremans, Leen Geuens, Bieke Govaerts, and Johan Geysen,

Oral presentation at SBS 2005, Geneva, Switzerland, September 2005

Abstract

and also

SelectScience Newswire, 18 october 2005

Slides

 

Current and Future Applications of Automated Microscopy

in Biotechnology and Drug Discovery Research

Johan Geysen, Peter Van Osta, Luc Bols, Bart Vanherck and Kris Ver Donck

Orally presented at: ‘Knowledge for Growth’ Conference, Flanders Expo, Gent, Belgium, 3rd June 2005.

Abstracts  |  Slides

 

Automated Bio-Imaging of Transglutaminase-1 with the

MIAS®-2 reader in Primary Human Epidermal Keratinocytes

Seeded with a Cell Printer

Marc Moeremans, Bieke Govaerts, Kris Ver Donck ,Kim Franssen*, Paul Stoppie* and Johan Geysen

In collaboration with Barrier Therapeutics*

Poster Presentation at “Knowledge for Growth’, Flanders Expo, Gent, Belgium, 3rd June 2005.

Abstract  |  Poster

 

Automated Image Analysis to Study the Early Effects of Antifungal Compounds on Growth and Differentiation

of  the Pathogenic Yeast Candida albicans

Kris Ver Donck, Karin Thevissen³, Gerrit Dispersyn², Isabelle François³, Marcel Borgers², Bruno Cammue³ & Johan Geysen

In collaboration with Barrier Therapeutics² and the Centre of Microbial and Plant Genetics, KU Leuven³

Poster Presentation at “Knowledge for Growth’, Flanders Expo, Gent, Belgium, 3rd June 2005.

Abstract  |  Poster

 

Development of an in vitro Method or the Evaluation of Pharmacological Agents
in the Differentiation and Maturation of Dendritic Cells

Leen Geuens, Kim Habets*, Marina Cools*, Johan Beetens*, Marcel Borgers*, Johan Geysen

In collaboration with Barrier Therapeutics*

Poster Presentation at “Knowledge for Growth’, Flanders Expo, Gent, Belgium, 3rd June 2005.

Abstract  |  Poster

 

High Information Content Across the Drug Discovery Value Chain:
Digital Imaging as a Key to R&D productivity

Johan Geysen

Workshop at the Discovery 2005 Summit – Montreux, 25 April 2005

Slides

 

Cytomics & Drug Discovery

Peter Van Osta, Kris Ver Donck, Luc Bols and Johan Geysen

Cytometry 69A:46

The 10th Leipziger Workshop and the 3rd International Workshop on Slide Based Cytometry April 2005 Leipzig, Germany

Abstract

 


2004


Turning a Microscopy Reader Into 'Eye and Brain'
of a Robot for Automated Cell Culture and Clone Selection

Johan Geysen, Luc Bols, Bieke Govaerts, Bart Van Herck, Kris Ver Donck, Peter Van Osta

SBS 2004, Orlando, Florida, USA, September 2004 – in collaboration with The automation Partnership

Abstract  |  related press release

A system designed for exploring the human cytome

 P. Van Osta, B. Vanherck, K. Ver Donck, L. Bols and J. Geysen (poster presentation)

European Microscopy Conference 2004, Antwerpen, Belgie, September 2004  -  Abstract

Accurate assignment of cytoplasmic structures to individual cells
in automated high volume image cytometry

Kris Ver Donck, Peter Van Osta, Luc Bols, Bart Vanherck, Johan Geysen (oral  presentation)

ISAC XXII, Montpellier, France, May 2004.  -  Abstract  

The M5 framework for exploring the Human Cytome

Peter Van Osta, Bart Vanherck, Kris Ver Donck, Luc Bols, Johan Geysen (plenary session oral)

Focus on Microscopy, Philadelphia, Pennsylvania, USA, April 2004  -  Abstract

Multimode microscopy and image cytometry
in ultra low light and in variable background conditions

Kris Ver Donck, Peter Van Osta, Luc Bols, Bart Vanherck, Johan Geysen (poster presentation)

ISAC XXII, Montpellier, France, May 2004.   -  Abstract  

Automated High Content Assays: Application Across The Drug Discovery Value Chain

Johan Geysen (speaker program)  -
 Practical Experiences of High-Content Screening in Drug Discovery, London, UK, April 2004.  -  Handouts (pdf, 2Mb)

Automated assessment of cell growth, confluence & compound-induced inhibition
using unlabeled skin-derived cells and brightfield microscopy

Johan Geysen, Luc Bols, Kim Franssen*, Leen Geuens, Bieke Govaerts, Paul Stoppie*, Kris Ver Donck, Peter Van Osta, Marcel Borgers*
In collaboration with Barrier Therapeutics*

65th meeting of the Society for Investigative Dermatology, Providence, Rhode Island USA, April 28-May 1 2004  -  Abstract  |  Poster


2003


Solutions for the Challenges in High-throughput Cell Based Screening

Johan Geysen, Peter Van Osta, Luc Bols, Bart Vanherck and Kris Ver Donck

SEBIOT 2003, Madrid, Spain, Plenary Session 5: From Proteins to Cells: Accelerating Cell Biology

abstract (pdf)  |  presentation slides (pdf, 2.5Mb)

Ultra-sensitive multimode microscopic reading in HTS

Kris Ver Donck, Peter Van Osta, Luc Bols, Bart Vanherck and Johan Geysen

SBS-2003, Portland, Oregon USA, abstract (pdf) 

Time-lapse projection of real time video reveals substantial detail
of C. elegans locomotion on agarose and swimming in liquid culture

Kris Ver Donck, Peter Van Osta, Luc Bols, Rock Pulak, Johan Geysen

2003 International C. elegans Meeting, Los Angeles, USA, Poster Abstract.   -  abstract (pdf)  |  poster (pdf)

Seamless integration of target validation, assay development and HTS
Johan Geysen (plenary speaker program)

SMI Conference Target Validation, London, UK, 2003.

Fast Assay Development for Multimode Microscopy Screening with a flexible HTS reader

Kris Ver Donck, Luc Bols, Peter Van Osta and Johan Geysen

6th MIPTEC 2003, Basel, Switzerland, abstract on published CD-ROM.    -  abstract (pdf)  |  poster (pdf)

Specialty solutions for drug discovery research: the MIAS®-2 reader allows you to focus on results
Johan Geysen   Drug Discovery & Technology Leader’s Summit, Montreux, Switzerland, 2003  -  poster

Bead-Based Assays Using COPAS™ Flow Sorting

Kris Ver Donck, Luc Bols, Rico Bongaarts, Peter Van Osta, Arwin J. Brouwer, Rob M. J. Liskamp, Johan Geysen, Don Perrault, Rock Pulak

Eurocombichem 2003, Copenhagen, Denmark  -  abstract (pdf)

 

 


2002


The principles of scale space applied to structure and colour in light microscopy

Peter Van Osta, Jan-Marc. Geusebroek, Kris Ver Donck, Luc Bols, Johan Geysen, Bart M. ter Haar Romeny

Proceedings of the Royal Microscopical Society, 37 (3): 161-166  -  full text (pdf)

A New Edge for High Content Screening:  The MIAS HCS Platform and eaZYX Imaging
Kris Ver Donck, Marc Vandermeeren, Luc Bols, Peter Van Osta, Yoshinobu Koyama & Johan Geysen

SBS-2002,  8th Annual conference, The Hague, The Netherlands, poster abstract 2471, p 204-205. 
abstract (pdf)  |  poster (pdf)

COPAS Flow Sorting:  Increased Speed & Flexibility for uHTS
Kris Ver Donck, Luc Bols, Rico Bongaerts, Peter Van Osta, Arwin J. Brouwer, Rob, M.J. Liskamp & Johan Geysen

SBS-2002,  8th Annual conference, The Hague, The Netherlands, poster abstract 2385, p 188.  -  abstract (pdf)  |  poster (pdf)

The Multi-Mode Mosaic framework for automated microscopy and analysis

Peter Van Osta, Kris Ver Donck, Jan-Marc Geusebroek, Luc Bols and Johan Geysen

Microscience 2002, London, UK, poster abstract  -  abstract (pdf) 

Enhanced One-step Nematode Recognition on micrographs
of Living C. elegans Cultures in 384-well Plates using Linear Scale Space Mathematics

Peter Van Osta, Kris Ver Donck, Jan-Mark Geusebroek, Luc Bols and Johan Geysen

2002 European C. elegans Meeting, Paestum, Italy, Poster  -  abstract (pdf)  |  poster (pdf)

Enhanced Analytical Performance of the C. elegans Flow Sorter COPAS BIOSORT:
Automated Re-analysis of Populations in Multi-well Plates
and Reading of Axially Distributed Positional Fluorescent Signals

Johan Geysen, Steve Alam, Anthony Ferrante, Peter Kalutkewitz, Peter Van Osta, Susan Zusman

2002 European C. elegans Meeting, Paestum, Italy, Session 3 (Part II) Workshop on techniques and technology, Oral abstract 32.   -  abstract (pdf)  |  slides (pdf)

Multi-parametric & Dual Color Fluorescent Analysis and Flow Sorting of C. elegans

Rico Bongaarts, Luc Bols, Anthony Ferrante, Brian Dell’Orfano, Susan Zusman & Johan Geysen

2002 European C. elegans Meeting, Paestum, Italy, Poster abstract  -  abstract (pdf)

At the higher end of High Content Screening:  The MIAS HTS imaging device

Kris Ver Donck, Peter Van Osta, Luc Bols, Johan Geysen,

5th Miptec 2002, Basel, Switzerland, poster abstract 82  -  abstract (pdf)

Assays beyond uHTS through COPAS flow sorting

Kris Ver Donck, Luc Bols, Rico Bongaarts, Peter Van Osta, Arwin J. Brouwer, Rob M.J. Liskamp, Johan Geysen,

5th Miptec 2002, Basel, Switzerland, poster abstract 34  -  abstract (pdf)  |  poster (pdf)